Moderated Poster Discussions - T3 Research/Science
Monday, April 13, 2026
4:30 pm - 6:15 pm
T3 Research/Science: Translation to practice, including comparative effectiveness research, post-marketing studies, clinical outcomes research, as well as health services, and dissemination & implementation research.
COMORBID CONGESTIVE HEART FAILURE INDEPENDENTLY PREDICTS ALL-CAUSE MORTALITY AND SEPSIS-RELATED MORTALITY IN HOSPITALIZED PATIENTS WITH BILIARY DUCT CALCULUS (Cardiology / Cardiovascular Disease)
Kwame Frimpong, MD, University of Missouri-Columbia Hospital
Biliary stones are associated with increased hospitalization and may be complicated by sepsis, shock, and death, particularly in patients with significant cardiovascular comorbidities. Congestive heart failure (CHF) may adversely affect physiologic reserve and tolerance to biliary obstruction, infection, and procedural interventions. We examined the association between CHF and clinical outcomes among patients hospitalized with biliary stones.
COMPARATIVE EFFECTIVENESS AND SAFETY OF EPLERENONE VERSUS SPIRONOLACTONE IN HEART FAILURE (Cardiology / Cardiovascular Disease)
Mohanad Qwaider, MD, MPH, University of Toledo
Mineralocorticoid receptor antagonists (MRAs) improve outcomes in patients with heart failure (HF), yet comparative real-world evidence between steroidal agents remains limited. Eplerenone and spironolactone differ in receptor selectivity and metabolic profiles, but their relative clinical effectiveness in contemporary HF practice is not well established.
FINERENONE VS EPLERENONE IN HEART FAILURE: A PROPENSITY-MATCHED REAL-WORLD ANALYSIS (Cardiology / Cardiovascular Disease)
Mohanad Qwaider, MD, MPH, University of Toledo
Mineralocorticoid receptor antagonists (MRAs) improve survival in heart failure (HF), but real-world comparative data between individual agents remain limited. Finerenone has demonstrated favorable cardiorenal effects in recent trials, while eplerenone has well-established benefits in HF. However, direct comparisons between these agents in routine clinical practice are lacking.
SEMAGLUTIDE THERAPY IN MANAGING LONG-TERM MAJOR ADVERSE CARDIOVASCULAR EVENTS (MACE) IN PATIENTS WITH DISSECTING CELLULITIS (Dermatology)
Molynna Nguyen, BS, University of Toledo College of Medicine and Life Sciences
Dissecting cellulitis (DC), also known as perifolliculitis capitis abscedens et suffodiens or Hoffman disease, is a chronic neutrophilic cicatricial alopecia. DC is part of the follicular-occlusion tetrad along with hidradenitis suppurativa (HS), acne conglobata, and pilonidal disease, all of which produce chronic inflammation in the skin. This persistent inflammatory state consequently contributes to damage other organs in the body. The widely popular GLP-1 receptor agonists combat many aspects of chronic inflammation, and when used in HS, showed a significant benefit in decreasing cardiovascular risk. However, studies fail to include or address their impact on DC patients, which could prove vital in broadening the patient population GLP-1 receptor agonists could help.
ENROLLING IS NOT ENOUGH: SOCIODEMOGRAPHIC PATTERNS OF RETENTION IN THE NIH RECOVER ADULT COHORT STUDY (Health Disparities / Diversity / Equity / Inclusion / Social Determinants / Ethics)
Jasmine Berry, MPH, Emory University School of Medicine
Recruiting and retaining a sociodemographically representative population remains a persistent challenge in large, longitudinal clinical studies. While substantial effort has focused on improving enrollment of historically underrepresented populations, less is known about patterns of retention over extended follow-up in the post-pandemic era. The NIH Researching COVID to Enhance Recovery (RECOVER) Adult Cohort Study was explicitly designed to enroll a population reflective of the U.S. adult population.
ENHANCING DIAGNOSIS OF PROSTATE CANCER WITH MRI IMAGING AND AI (Hematology and Oncology / Bone Marrow Transplant)
Kathleen Miao, MD, Icahn School of Medicine at Mount Sinai
Prostate cancer remains a major public health burden and is among the most frequently diagnosed malignancies in men worldwide. Prognosis is strongly dependent on early and accurate disease characterization, as timely identification of clinically significant tumors enables curative intervention. Multiparametric MRI (mpMRI) has become central to prostate cancer evaluation. Artificial intelligence—based image analysis offers an opportunity to enhance diagnostic accuracy and efficiency especially in underserved areas.
COMPREHENSIVE GERIATRIC ASSESSMENT AND CHEMOTHERAPY DOSING IN OLDER ADULTS WITH COLORECTAL CANCER IN A COMMUNITY ONCOLOGY SETTING (Hematology and Oncology / Bone Marrow Transplant)
Claire Sim, Englewood Hospital and Medical Center
Older adults with colon cancer represent a heterogeneous population with substantial variation in functional status, comorbidities, and tolerance to systemic therapy. The American Society of Clinical Oncology (ASCO) recommends routine comprehensive geriatric assessment (CGA) for patients aged ≥ 65 years receiving systemic cancer therapy to guide treatment decisions and supportive care. Similarly, National Comprehensive Cancer Network (NCCN) guidelines recommend the use of geriatric assessments and validated tools to estimate chemotherapy toxicity risk and inform dose adjustments, supportive care needs, and monitoring intensity. Implementation of guideline-recommended CGA often requires a multidisciplinary team and dedicated institutional resources, which can be challenging in community-based hospital settings. To address this gap, we piloted a standardized geriatric assessment program for patients with colon cancer at Englewood Hospital, a community-based hospital in New Jersey.
NETWORK META-ANALYSIS OF THE ADDITION OF DOCETAXEL TO DOUBLET THERAPIES (Hematology and Oncology / Bone Marrow Transplant)
Zhenni Stepanyan, BS, Armenian American Medical Society
Metastatic castration-sensitive prostate cancer treatment has progressed from androgen deprivation therapy (ADT) alone to include a variety of different therapies and approaches. Clinical trials such as LATITUDE and CHAARTED show that adding docetaxel or abiraterone, respectively, to ADT improves survival in high volume disease than in ADT alone. Triplet trials, such as PEACE-1 and ARASENS, worked to examine the effects of therapy that combines docetaxel, an ARPI, and ADT. The outcomes compared with docetaxel plus ADT alone improve survival.
THE EFFECTIVENESS OF CABOZANTINIB AND LENVATINIB FOR TREATMENT OF ADVANCED RENAL CELL CARCINOMA (Hematology and Oncology / Bone Marrow Transplant)
Zhenni Stepanyan, BS, Armenian American Medical Society
Renal cell carcinoma is the most common type of kidney cancer in adults, in which cancer cells are found in the linings of the tubules. Treatments include surgery, radiation therapy, immune therapy, and targeted therapy. Targeted therapies, Cabozantinib and Lenvatinib, are often used to treat RCC as monotherapies or are paired with immune therapies such as Pembrolizumab. Although both therapies demonstrate clinical benefit, their relative comparative performance remains unclear because most trials evaluate them against standard treatments such as Sunitinib/Everolimus rather than against each other.
OUTCOMES OF ORAL ANTICOAGULATION IN PATIENTS WITH REMOTE INTRACRANIAL HEMORRHAGE AND NEW-ONSET ATRIAL FIBRILLATION (Neurology)
Madhu Vishnu Sankar Reddy Rami Reddy, BS, The University of Toledo College of Medicine and Life Sciences
Patients with prior intracranial hemorrhage (ICH) who later develop new-onset atrial fibrillation (AF) present a major therapeutic dilemma. Evidence guiding initiation of oral anticoagulation (OAC) in this anticoagulation-naïve, high-risk population is limited, as most trials focus on resumption of therapy after hemorrhage or exclude prior ICH altogether.
DOES ANXIETY MODIFY CARDIOVASCULAR RISK ASSOCIATED WITH STIMULANT THERAPY IN ADULTS WITH ADHD? A REAL-WORLD COHORT STUDY (Psychiatry)
Grant Nelson, University of Toledo College of Medicine and Life Sciences
Attention-deficit/hyperactivity disorder (ADHD) is commonly treated with stimulant and non-stimulant pharmacotherapies, with stimulant use previously associated with increased cardiovascular (CV) risk. Anxiety disorders are highly prevalent among adults with ADHD and are independently linked to adverse cardiovascular outcomes through mechanisms including autonomic dysregulation and heightened sympathetic activity. However, whether comorbid anxiety modifies cardiovascular risk among adults with ADHD treated with stimulant versus non-stimulant medications remains unclear.
IDENTIFYING FEATURES OF THE COPDGENE AND GOLD DIAGNOSTIC SCHEMAS FROM INPATIENT NOTES, IMAGING REPORTS, AND PROCEDURE NOTES WITH LARGE LANGUAGE MODELS: A PILOT STUDY (Pulmonary / Critical Care)
Mao-Yuan Chen, MD, University of California San Francisco
Chronic obstructive pulmonary disease (COPD) affects 14.2 million Americans (Liu 2023), is the fourth leading cause of death and is responsible for significant morbidity (Berry 2010). High-quality studies using real-world evidence and comparative effectiveness research provide a faster route than gold-standard randomized controlled trials, to which valid computable phenotypes (CP) are key. These studies can be applied to the field of COPD in identifying appropriate treatment strategies leading to better outcomes. However, commonly used ICD-10-based administrative data approaches to identifying such cases have both low sensitivity and specificity, which decrease clinical details needed to create useful CPs. Unstructured data like clinical notes can improve existing ICD-10-based algorithms by incorporating standard diagnostic criteria.
THE IMPACT OF TUMOR LOCATION ON PERIOPERATIVE AND LONG-TERM OUTCOMES AFTER RESECTION OF PANCREATIC DUCTAL ADENOCARCINOMA (Surgery)
Madhu Vishnu Sankar Reddy Rami Reddy, BS, The University of Toledo College of Medicine and Life Sciences
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest solid malignancies. Although tumor location has been proposed as a prognostic factor, prior studies report conflicting results. Whether anatomical site independently influences perioperative risk and long-term survival after resection remains unclear.
ASSESSING PRE-MEDICAL STUDENTS' SYSTEMS-LEVEL LITERACY OF U.S. HEALTHCARE PRACTICE (Health Disparities / Diversity / Equity / Inclusion / Social Determinants / Ethics)
Sophie Keshishian, University of California, Berkeley
The administrative complexity of the U.S. healthcare system represents a growing challenge for physicians and trainees, contributing to burnout and reduced clinical efficiency. National surveys show that approximately 29—40% of physicians would not choose medicine again, with administrative burden, reimbursement pressure, and work-life imbalance cited as leading reasons, particularly in primary care fields. Physicians in high-administrative, lower-reimbursement specialties such as family medicine, OB-GYN, and emergency medicine report higher burnout rates than many procedure-based specialties, suggesting that system complexity plays a role not only in burnout, but also in specialty selection for trainees. Studies estimate that physicians spend up to 25-40% of their workday on administrative tasks rather than direct patient care, plus time spent on EHR outside of work hours. Despite this reality, pre-medical and even medical curricula offer limited formal education on healthcare delivery models, insurance structures, and administrative workflows.
BALANCING RISK AND REWARD IN HIP RESURFACING FOR DEVELOPMENTAL DYSPLASIA OF THE HIP: A SYSTEMATIC REVIEW AND META-ANALYSIS (Surgery)
Jean Shanaa, BS, California Northstate College of Medicine
As interest in hip resurfacing arthroplasty (HRA) expands to complex pathologies, developmental dysplasia of the hip (DDH)has emerged as a challenging but increasingly considered indication. Although severe DDH often precludes resurfacing because of distorted anatomy, mild cases (Crowe I and II) may provide favorable conditions.
CONTRAST-ENHANCED ULTRASOUND AS A REAL-TIME INTRAOPERATIVE ADJUNCT FOR GLIOMA RESECTION: TECHNICAL NUANCES, IMAGING CHALLENGES, AND OUTCOME EVIDENCE (Surgery)
Supraneeth Yedem, University of Missouri-Kansas City School of Medicine
Maximal safe resection is a key predictor of overall and progression-free survival in both low and high-grade glioma patients [1,2]. However, conventional neuronavigation is limited by intraoperative brain shift, with tissue displacement exceeding 1 cm and resulting in navigation inaccuracies [3]. Although intraoperative magnetic resonance imaging (iMRI) mitigates brain shift, its high cost ($5-10 million), prolonged operative time, and logistical complexity restrict widespread use [4-7]. Contrast-enhanced ultrasound (CEUS) utilizes intravenously administered gas-filled micro-bubbles that generate nonlinear acoustic signals, enhancing visualization of tumor micro-perfusion and microvascular architecture with high signal-to-noise ratio [8,9].
SMALL TRAVELERS, SAFER TRANSPORTS: A PEDIATRIC TRANSPORT MEDICINE QUALITY IMPROVEMENT PROJECT (General Medicine)
Skylar Ketteler, BS, Western Michigan University Homer Stryker MD School of Medicine
Pediatric inter-facility transport is a critical component of modern healthcare, ensuring timely and safe access to higher levels of care for ill and injured children. With the increased regionalization of pediatric services, the demand for pediatric inter-facility transport continues to grow. Despite published quality metrics for safe inter-facility transport (Ground & Air Medical Quality in Transport [GAMUT], 2024), there is limited data tracking at Bronson Children’s Hospital. This QI initiative aims to evaluate the current pediatric transport process at Bronson Children’s Hospital, identify gaps in documentation and care delivery, and develop sustainable interventions to enhance transport safety and continuity of care.